Analysis of pig DNA has offered insights into important correlations with muscle growth. This can provide tools to help predict piglet growth and support pig breeding programmes. Researchers from the Roslin Institute and the Centre for Tropical Livestock Genetics and Health sought to find and examine regions of DNA that regulate muscle development in piglets. The team used a technique to study DNA in frozen tissue, which is advantageous because it can help limit the numbers of animals used for research. They applied this technique to samples from muscle in piglets at various stages of development, to pinpoint regions of DNA that control activity in genes linked to muscle growth, and to study activity in these genes. Variations in regions of DNA were observed between small and large piglets. These variations suggest a difference in how DNA is regulated – which in turn governs muscle growth – between large and small piglets. Researchers hope to explore their data further to identify variations in the genetic code of pigs that are linked to growth, and better understand how these differences regulate the activity of key genes involved in muscle development, to inform pig breeding programmes.
